Amoxicillin CAS NO.26787-78-0

AMOXICILLIN alpha-Amino-p-hydroxybenzylpenicillin; p-Hydroxyampicillin;AMPC; Anemolin; Aspenil; Augmentin; Betamox; Bristamox; Cabermox; Cemoxin; C…

AMOXICILLIN alpha-Amino-p-hydroxybenzylpenicillin; p-Hydroxyampicillin;AMPC; Anemolin; Aspenil; Augmentin; Betamox; Bristamox; Cabermox; Cemoxin; Cilamox; Clamoxyl; Clamoxyl (Trihydrate); Cuxacillin; 248-003-8 C16H19N3O5S-3H2O 3006 N/A N/A N/A AMPICILLIN is a semisynthetic antibiotic, a member of the penicillin family of antibiotics. To extend the usefulness of the penicillins to the treatment of infections caused by gram-negative rods, the broad-spectrum penicillins (ampicillin, amoxicillin, carbenicillin, and ticarcillin) were developed. It is created by attaching acid radicals to the central structure of 6-aminopenicillanic acid. Chemically, it is D-(-)-6-(2-amino-2-phenylacetamido)-3,3-dimethyl-7 -oxo-4-thia-1-azabicyclo [3.2.0] heptane-2-carboxylic acid trihydrate. Similar in action to penicillin G--the most widely used natural penicillin--ampicillin (or alpha-aminobenzylpenicillin) is more stable in stomach acids and therefore may be given orally; it is also more active against certain strains of bacteria.APPLICATIONIt is used regularly to treat common urinary-tract infections, some respiratory infections, and bacterial meningitis in children, although many strains of Hemophilus influenzae (the most common cause of bacterial meningitis) are now resistant to ampicillin, and it commonly is used along with other drugs. The potential side effects of ampicillin are similar to those of other penicillins--i.e., chiefly allergic reactions ranging from skin rashes and hives to life-threatening anaphylactic shock (very rare). People who are allergic to other drugs in this family are also likely to react to ampicillin. The incidence of skin rashes is higher with ampicillin than with other penicillins, a factor that suggests a possible toxic reaction, as well as a truly allergic response. AMOXICILLIN is a semisynthetic antibiotic, an analog of ampicillin, with a broad spectrum of bactericidal activity against many gram-positive and gram-negative microorganisms. Chemically it is (2S,5R,6R)-6-[(R)-(-)-2-amino-2-(p-hydroxyphenyl)acetamido]-3,3-dimethyl-7-oxo- 4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid trihydrate. Amoxicillin is useful in treating urinary tract infections caused by gram-negative rods as well as in treating typhoid and enteric fevers.IDENTIFICATION: Comply Test CLARITY OF SOLUTION: Complies test OPTICAL ROTATION: +290° - +315° HEAVY METALS: 20 ppm max N,N-DIMETHYLANILINE: 20 ppm max SULFATED ASH: 0.5% max WATER: 11.50% - 14.50% PH: 3.5 - 5.5 (0.25% W/V Solution) BULK DENSITY: 0.65 - 0.8 gr/ml (Compact Type)